Cystamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cystamine 是游离硫醇半胱胺的二硫化物形式。Cystamine 是一种转谷氨酰胺酶 (Tgase) 抑制剂，具有口服活性。Cystamine 对 caspase-3 也有抑制活性，IC50 值为 23.6 μM。Cystamine 可用于亨廷顿舞蹈病（HD）等多种疾病的研究。

Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione.Western Blot Analysis Cell Line:uman neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner.

Cystamine (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice.Animal Model:R6/2 transgenic HD mice Dosage:112, 225 mg/kg Administration:Intraperitoneal or oral, dailyResult:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.

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Apoptosis

Caspase

Caspase

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51-85-4

152.28

C4H12N2S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (656.69 mM; 超声助溶 ) H2O 中的溶解度 : 100 mg/mL (656.69 mM; 超声助溶)

NCCSSCCN

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(-20℃)

With Ice Pack

≥ 2 years