Cycleanine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cycleanine 具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。

Cycleanine has potent antibacterial antifungal antiplasmodial and cytotoxic activities.

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM.Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells. Cell Cytotoxicity AssayCell Line:Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cellsConcentration:20 μM Incubation Time:48 hoursResult:Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.Western Blot Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:24 hours Result:Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.Apoptosis Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:48 hours Result:Caused a significant increase of the population of both early and late apoptotic cells.Cell Cycle Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:48 hours Result:Increased the percentage of Ovcar-8 cells in subG1.

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM.

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Others

Other Targets

Others

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518-94-5

622.7

C38H42N2O6

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (8.03 mM)

[H][C@]12Cc3ccc(Oc4c(OC)c(OC)cc5CCN(C)[C@]([H])(Cc6ccc(Oc7c(OC)c(OC)cc(CCN1C)c27)cc6)c45)cc3

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(-20℃)

With Ice Pack

≥ 2 years