Crocin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一般说明藏红花中发现的高度不饱和二萜二羧酸酯。

General descriptionA highly unsaturared diterpene dicarboxylic acid ester found in saffron.

Cell Viability Assay Cell Line:HCT116 Concentration:0, 50, 100, 150, 200, 250, 300, 350, 400, and 450 μM Incubation Time:24 h Result:Weakened the cell vitality in a concentration-dependent manner.Apoptosis Analysis Cell Line:HCT116 Concentration:150, 200 μM Incubation Time:24 hResult:Facilitated apoptosis of HCT-116 cells in a concentration-dependent manner.Abated the colony number and downregulated the positive expression of Ki-67.Western Blot Analysis Cell Line:HCT116 Concentration:150, 200 μM Incubation Time:24 h Result:Decreased the levels of p-JAK2, p-STAT3, and p-ERK, as well as the ratios of p-JAK2/JAK2, p-STAT3/STAT3, and pERK/ERK.

Animal Model:Bleomycin-induced pulmonary fibrosis in rat Dosage:20 mg/kg Administration: p.o.Result:Reduced the expression of TLR4 and IL-10.Reduced the expression of TNF-α and TGF-β1.

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Others

Other Targets

Others

Other Indications

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42553-65-1

976.96

C44H64O24

>98% (HPLC)

DMSO: 10 mM

C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)/C)/C)/C=C/C=C(/C(=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)\C

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(-20℃)

With Ice Pack

≥ 2 years