Compstatin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Compstatin 是一种环状十三肽，最初是从噬菌体展示文库中发现的，是一种高效、选择性的 C3 抑制剂。Compstatin 与狒狒 C3 结合，并且对狒狒血液中的蛋白水解具有抗性（与人类相似）；坎普他汀仅抑制灵长类补体系统的激活。

Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans); Compstatin inhibits only the activation of primates' complement system.Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Pig xenografts survival is significantlylonger in the Compstatin perfused group than in the control group. At rejection the biopsy samples obtained from kidneysperfused with Compstatin show less deposition of C3 and fibrin than do the control kidneys.

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Animal Model:Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg.Dosage:50, 25 mg/kg 60 min after heparin and 2 min before protamine.Administration:A bolus injection.Result:Completely inhibited complement activation induced by heparin–protamine complexes.

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Immunology/Inflammation

Complement System

Complement System

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206645-99-0

1550.77

C66H99N23O17S2

>98% (HPLC)

DMSO:300 mg/mL (193.45 mM)

CC[C@H](C)[C@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years