Clofoctol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clofoctol 是一种抑菌抗生素。用于治疗革兰氏阳性菌引起的呼吸道和耳鼻喉感染。

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.

Cell Viability Assay Cell Line:Prostate cancer cell lines: LNCaP, DU145, PC3, LAPC4, CWR22Rv1 and C42BConcentration:0-100 μMIncubation Time:72 h Result:Inhibited cell growth with IC50 values ranging from 10 to 15 μM.Cell Viability Assay Cell Line:PC3 Concentration:0, 10 and 20 μM Incubation Time:24 h Result:Induced a G1 arrest.RT-PCRCell Line:PC3 Concentration:0, 5, 10, 15, 20 and 30 μM Incubation Time:24 h Result:Increased the splicing of XBP-1 mRNA in PC3 cells in a dose-dependent manner. Dose-dependently decreased PstI digestion products from XBP-1 mRNA.Western Blot Analysis Cell Line:PC3 Concentration:0, 5, 10, 15, 20, 25 and 30 μM Incubation Time:0, 0.5, 1, 3, 6 and 9 h or 24 h (cell cycle)Result:Dose- and time-dependently increased the level of phosphorylated eIF2α, up-regulated CHOP expression, and increased the expression of BiP. Led to a dose-dependent decrease in the levels of cyclin A and cyclin D1.

Animal Model:Male athymic nude mice (BALB/c, nu/nu-NCr) aged 4–6 weeks, human prostate cancer xenograft modelDosage:175 mg/kg Administration:Intraperitoneal injection, daily for 37 days Result:Significantly inhibited PC3 tumour growth, tumour weight was also reduced by 60%.Animal Model:K18-hACE2 transgenic C57BL/6J mice with SARS-CoV-2 infection Dosage:62.5 mg/kg Administration:Intraperitoneal injection, 1h and 8h post-infection Result:Induced body weight loss, reduced the viral load in the lungs. The expression of transcripts encoding IL-6, TNFα, IL12p40, IFNβ, IFNγ and the interferon-stimulated genes (ISG) Mx1, Ifi44 and ISG15 was markedly reduced.Animal Model:8–10 week-old female C57BL/6J miceDosage:62.5mg/kg Administration:Intraperitoneal injection, once (Pharmacokinetics) Result:Reached concentrations up to 61 μM in the lungs and remained above this level for almost 4h as early as 30 min after injection.

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Others

Other Targets

Others

Infection

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37693-01-9

365.35

C21H26Cl2O

>98% (HPLC)

DMSO: 10 mM

CC(C)(C)CC(C)(C)C1=CC(CC2=C(Cl)C=C(Cl)C=C2)=C(O)C=C1

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(-20℃)

With Ice Pack

≥ 2 years