Clindamycin ( U 21251 )

产品货号. M12825 CAS No. 18323-44-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Clindamycin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

克林霉素通过作用于 50S 核糖体来抑制蛋白质合成。
产品描述

Clindamycin inhibits protein synthesis by acting on the 50S ribosomal.
体外实验

Cell Viability Assay Cell Line:THP-1 cells with stimulated E. coli O55:B5 Concentration:3.13-50 μg/mL Incubation Time:1-18 h Result:Reduced TNF-α concentrations after pretreatment for 4 or 18 h at 25 and 50 μg/mL.Cell Viability Assay Cell Line:Osteoblast cell culture model Concentration:0-500 μg/mL Incubation Time:24-72 h Result:Increased alkaline phosphatase (ALP)-activity at 10 μg/mL at 24 and 48 h.Increased LDH values at 500 μg/mL at 24 and 48 h, indicating cytotoxicity.Increased calcification at 10 and 25 μg/mL,decreased or no calcification was found at 50 μg/ml.
体内实验

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同义词

U 21251
通路

Others
靶点

Other Targets
受体

Others
研究领域

Other Indications
适应症

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CAS Number

18323-44-9
分子量

424.98
分子式

C18H33ClN2O5S
纯度

>98% (HPLC)
溶解度

DMSO:85 mg/mL (200.0 mM); Ethanol:85 mg/mL (200.0 mM); Water:<1 mg/mL (<1 mM)
SMILES

CCC[C@@H]1C[C@@H](C(N[C@@H]([C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C)=O)N(C1)C
化学全称

(2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide