Chlorothalonil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

百菌清是一种高效、低毒的广谱杀菌剂。

Chlorothalonil is a broad-spectrum fungicide with high efficiency and low toxicity. Chlorothalonil is widely used to control various pests such as fruit trees and vegetable leaves. Chlorothalonil also has good control effects on various diseases such as rice, wheat, and cotton.

RT-PCR Cell Line:Caco-2 (Human colorectal adenocarcinoma cell line) Concentration:0.6 μg/mL, 1.2 μg/mL , 2.4 μg/mL, 4.8 μg/mL Incubation Time:1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days Result:Down-regulated the mRNA levels of TJ genes (ZO-1, OCLN, and CLDN1), polar marker genes (SI), and anti-apoptotic genes (BCL-2), and up-regulated the mRNA levels of apoptosis-related genes (BAD, BAX, CASP3, and CASP8).Western Blot Analysis Cell Line:Caco-2 (Human colorectal adenocarcinoma cell line) Concentration:0.6 μg/mL, 1.2 μg/mL , 2.4 μg/mL Incubation Time:4 days Result:Decreased levels of the TJ protein network (ZO-1 and CLDN1).Increased the expression levels of P-ERK1/2, PJNK and P-p38 and reduced levels of ERK1/2, JNK and p38.( All are mitogen-activated protein kinase (MAPK) signaling pathway-related proteins)

Animal Model:ICR mouse model of pregnancy Dosage:100 mg/kg, 400 mg/ kg, 600 mg/kg Administration:Oral gavage (p.o.); Once daily for 18 days Result:Reduced weight gain in pregnant mice at doses of 400 mg/kg and 600 mg/kg throughout pregnancy by 36% and 48%, respectively.Significantly increased embryo mortality at doses of 400 mg/kg and 600 mg/kg.Significantly reduced number of live births (28%).Reduced mean fetal weight (22% to 39%) at doses of 400 and 600 mg/kg.Animal Model:ICR male mice model Dosage:0.1mg/kg, 1 mg/ kg, 10 mg/kg Administration:Oral gavage (p.o.); Once daily for 5 weeks Result:Decreased sperm motility in ICR mice.At doses of 1 mg/kg and 10 mg/kg, decreased the protein factors A-myb, GDNF and DDX4, and finally interrupted the spermatogenesis process.Decreased the sperm marker Acrosin and PNA in a dose-dependent manner at doses of 1 mg/kg and 10 mg/kg.At doses of 1 mg/kg and 10 mg/kg, Significantly reduced the number of estrogen receptor Alpha (ERα) positive stromal cells in mouse testis.Decreased AKT levels in the testis, but did not change p-AKT levels.Disrupted the methylation of histones and DNA.

DAC 2787 | Daconil | Daconil M

GPCR/G Protein

Antibacterial

mGlu7| mGlu8

——

——

1897-45-6

265.9

C8Cl4N2

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (125.34 mM)

Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl

——

(-20℃)

With Ice Pack

≥ 2 years