Chetomin ( Chetomin; CTM; NSC-289491; NSC 289491 )

产品货号. M17999 CAS No. 1403-36-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Chetomin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
产品描述

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
同义词

Chetomin; CTM; NSC-289491; NSC 289491
通路

Others
靶点

Other Targets
受体

HIF-1
研究领域

Cancer
适应症

——

CAS Number

1403-36-7
分子量

710.87
分子式

C31H30N6O6S4
纯度

98%
溶解度

——
SMILES

CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
化学全称

2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

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