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Carbetocin

CAS No. 37025-55-1

Carbetocin ( —— )

产品货号. M20952 CAS No. 37025-55-1

卡贝缩宫素是一种产科化合物,用于控制产后出血和产后出血。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥405 有现货
10MG ¥608 有现货
25MG ¥1280 有现货
50MG ¥2357 有现货
100MG ¥3767 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Carbetocin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    卡贝缩宫素是一种产科化合物,用于控制产后出血和产后出血。
  • 产品描述
    Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.(In Vitro):Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (Ki=13 nM), E123 (Ki=56 nM), and E1234 (Ki=37 nM).(In Vivo):Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile.Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat.
  • 体外实验
    Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (Ki=13 nM), E123 (Ki=56 nM), and E1234 (Ki=37 nM).
  • 体内实验
    Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile. Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat. Animal Model:Male Sprague-Dawley rats weighing between 300 and 500 g Dosage:2, 6.4, 20 mg/kg Administration:IP; single dose Result:Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Oxytocin Receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    37025-55-1
  • 分子量
    988.16
  • 分子式
    C45H69N11O12S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:31 mg/mL (31.37 mM)
  • SMILES
    CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Theunissen F J Lester C Pujar Y V . Current research on carbetocin and implications for prevention of postpartum haemorrhage[J]. Reproductive Health 2018 15(S1):94-.
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