• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Carbazochrome

CAS No. 69-81-8

Carbazochrome ( Carbazochrome | AC-17 | AC 17 | AC17 | Adona )

产品货号. M19012 CAS No. 69-81-8

卡唑色素是一种抗出血剂或止血剂,可通过引起血液中血小板聚集和粘附形成血小板栓来停止血流,从而阻止开放性伤口的血流。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥437 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Carbazochrome
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    卡唑色素是一种抗出血剂或止血剂,可通过引起血液中血小板聚集和粘附形成血小板栓来停止血流,从而阻止开放性伤口的血流。
  • 产品描述
    Carbazochrome?is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on its effectiveness and the severity of possible side effects remains to be fairly inconclusive.?Carbazochrome?has been investigated for use in the treatment of hemorrhoids in a mixture with?troxerutin.(In Vitro):Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner. Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.(In Vivo):Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats.
  • 体外实验
    Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3in a concentration-dependent manner.Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.
  • 体内实验
    Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Animal Model:Male Sprague-Dawley rats weighing 180-230 g Dosage:10 mg/kg Administration:I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).Result:Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
  • 同义词
    Carbazochrome | AC-17 | AC 17 | AC17 | Adona
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    myosin light-chain kinase| PLA2
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    69-81-8
  • 分子量
    236.23
  • 分子式
    C10H12N4O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 5 mg/mL (21.17 mM)
  • SMILES
    OC1C2=C/C(=N/NC(=O)N)/C(=O)C=C2N(C1)C
  • 化学全称
    (Z)-2-(3-hydroxy-1-methyl-6-oxo-1,2,3,6-tetrahydro-5H-indol-5-ylidene)hydrazine-1-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Cecilia I, et al. Can Vet J. 2009 Aug; 50(8): 821–827.
产品手册
关联产品
  • 3-Hydroxyxanthyletin

    3'-Hydroxyxanthyletin showed antimycobacterial activities against Mycobacterium tuberculosis H(37)R(V) in vitro with MIC values of 16 microg/ml.

  • Silver nitrate

    硝酸银在弱酸性或中性 pH 条件下与选择性氨基酸残基结合,使其适合作为蛋白质鉴定的染色剂。

  • Chlorpropham

    氯苯胺灵用作植物生长调节剂和除草剂。