• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Carbadox

CAS No. 6804-07-5

Carbadox ( Carbadoxum | Fortigro | Getroxel | CCRIS-3002 | CCRIS 3002 | CCRIS3002 | HSDB7028 )

产品货号. M15595 CAS No. 6804-07-5

一种抗菌剂,已在兽医实践中用于治疗猪痢疾和肠炎并促进生长。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥340 有现货
200MG ¥462 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Carbadox
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    一种抗菌剂,已在兽医实践中用于治疗猪痢疾和肠炎并促进生长。
  • 产品描述
    An antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. (In Vitro):The results of MTT assay demonstrate a dose-dependent decrease in mitochondrial activity in Vero cells at all concentrations of Carbadox. Treatment with Carbadox at the highest concentration of 160 μg/mL results in cell viability down to only 12%. Cells following Carbadox treatment show a dose-dependent increase of the DNA migration (p<0.01). The nuclear division index (NDI) reduces markedly with the increase doses of Carbadox.(In Vivo):Alpha diversities (Shannon diversity, Heips evenness, and inverse Simpson indices) of samples from medicated piglets compare to non-medicated piglets are significantly different at 2, 3, and 4 days after continuous Carbadox, but not different in either late Carbadox or at any time during the withdrawal period. Analysis of the community structure of bacteria in animals shows significant differences at days 3 and 4 of early Carbadox treatment ([R=0.32, p=0.015] and [R=0.54, p=0.003], respectively), but not before starting antibiotic treatment (p=0.82). No significant differences in E. coli colony forming units (CFUs) are observed during the Carbadox-treatment period of the study or late in the withdrawal period. E. coli CFUs are significantly different between the medicated and non-medicated groups on day 2 after the withdrawal of Carbadox.
  • 体外实验
    The results of MTT assay demonstrate a dose-dependent decrease in mitochondrial activity in Vero cells at all concentrations of Carbadox. Treatment with Carbadox at the highest concentration of 160 μg/mL results in cell viability down to only 12%. Cells following Carbadox treatment show a dose-dependent increase of the DNA migration (p<0.01). The nuclear division index (NDI) reduces markedly with the increase doses of Carbadox.
  • 体内实验
    Alpha diversities (Shannon diversity, Heips evenness, and inverse Simpson indices) of samples from medicated piglets compare to non-medicated piglets are significantly different at 2, 3, and 4 days after continuous Carbadox, but not different in either late Carbadox or at any time during the withdrawal period. Analysis of the community structure of bacteria in animals shows significant differences at days 3 and 4 of early Carbadox treatment ([R=0.32, p=0.015] and [R=0.54, p=0.003], respectively), but not before starting antibiotic treatment (p=0.82).No significant differences in E. coli colony forming units (CFUs) are observed during the Carbadox-treatment period of the study or late in the withdrawal period. E. coli CFUs are significantly different between the medicated and non-medicated groups on day 2 after the withdrawal of Carbadox.
  • 同义词
    Carbadoxum | Fortigro | Getroxel | CCRIS-3002 | CCRIS 3002 | CCRIS3002 | HSDB7028
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    6804-07-5
  • 分子量
    262.22
  • 分子式
    C11H10N4O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    O=C(OC)[N+]([O-])([O-])/N=C/C1=NC2=CC=CC=C2N=C1
  • 化学全称
    Carbazic acid, 3-(2-quinoxalinylmethylene)-, methyl ester, N(sup 1),N(sup 4)-dioxide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Bearson BL, et al. Front Microbiol. 2014 Feb 11;5:52.
产品手册
关联产品
  • Br-PEG7-Br

    Br-PEG7-Br 是一种基于 PEG 的 PROTAC 连接子,可用于 PROTAC 的合成。

  • Isowighteone

    Isowighteone, a compound that is not naturally produced in this species, accumulated by medicago truncatula hairy roots expressing LaPT1, indicates a strategy for metabolic engineering of novel antimicrobial compounds in legumes; it may have antimicrobial activity against fungal pathogens of plants.

  • NN-Dimethyl-p-phenyl...

    N,N-二甲基对苯二胺(DPD、DMPD)是一种芳香胺,主要用作生产染料的中间体。