CW069 ( CW069; CW-069; CW 069 )

产品货号. M18087 CAS No. 1594094-64-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CW069
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CW069(IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
产品描述

CW069 is an allosteric inhibitor of HSET. CW069 showed marked activity against HSET in vitro. The inhibitor induced multipolar mitoses only in cells containing supernumerary centrosomes. CW069 therefore constitutes a valuable tool for probing HSET function and, by reducing the growth of cells containing supernumerary centrosomes, paves the way for new cancer therapeutics.
同义词

CW069; CW-069; CW 069
通路

Others
靶点

Other Targets
受体

HSET
研究领域

Cancer
适应症

——

CAS Number

1594094-64-0
分子量

500.33
分子式

C23H21IN2O3
纯度

98%
溶解度

DMSO : ≥ 52 mg/mL; 103.93 mM
SMILES

O=C(O)c1cc(I)ccc1NC(=O)[C@@H](NCc1ccccc1)Cc1ccccc1
化学全称

5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-benzoic acid

1. Watts CA, et al. Chem Biol. 2013, 20(11), 1399-1410.

计算器

产品手册

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