
CUR61414
CAS No. 334998-36-6
CUR61414 ( —— )
产品货号. M26658 CAS No. 334998-36-6
CUR61414 是一种细胞渗透性 Hedgehog 信号通路抑制剂 (IC50: 100-200 nM),并选择性结合 smoothened (Smo) (Ki: 44 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥551 | 有现货 |
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5MG | ¥915 | 有现货 |
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10MG | ¥1531 | 有现货 |
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25MG | ¥3054 | 有现货 |
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50MG | ¥4690 | 有现货 |
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100MG | ¥6707 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CUR61414
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CUR61414 是一种细胞渗透性 Hedgehog 信号通路抑制剂 (IC50: 100-200 nM),并选择性结合 smoothened (Smo) (Ki: 44 nM)。
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产品描述CUR61414 is an inhibitor of cell permeable Hedgehog signaling pathway (IC50: 100-200 nM) and selectively binds to smoothened (Smo) (Ki: 44 nM). CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.(In Vitro):CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells.(In Vivo):CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin.
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体外实验CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells.
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体内实验CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number334998-36-6
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分子量550.7
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分子式C31H42N4O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (181.59 mM)
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SMILESCOc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Uesawa M, Muroi K, Ozawa K. Plasmapheresis-refractory transplantation-associated thrombotic microangiopathy successfully treated with pravastatin and limaprost alfadex. Ther Apher Dial. 2013 Aug;17(4):462-3.
产品手册




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