CTS-1027 ( RS-130830 | Ro-1130830 | CTS1027 | CTS-1027 | RS130830 | Ro1130830 )

产品货号. M13024 CAS No. 193022-04-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CTS-1027
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种有效、选择性、广谱 MMP 抑制剂，对 MMP2、3、8、9、12、13 和 14 的 Ki 值 <9 nM。
产品描述

A potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14, but not MMP1 and 7; displays little or no activity for other proteinases including caspases, the initiator and effector proteinases of apoptosis; attenuates hepatocyte apoptosis, liver injury and hepatic fibrosis, and is an attractive agent as a potential hepato-protective agent in HCV patients.HCV Infection Phase 2 Clinical.
体外实验

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体内实验

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同义词

RS-130830 | Ro-1130830 | CTS1027 | CTS-1027 | RS130830 | Ro1130830
通路

Metabolic Enzyme/Protease
靶点

MMP
受体

MMP
研究领域

Infection
适应症

HCV Infection

CAS Number

193022-04-7
分子量

425.8832
分子式

C19H20ClNO6S
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

c1cc(ccc1Oc2ccc(cc2)Cl)S(=O)(=O)CC3(CCOCC3)C(=O)NO
化学全称

2H-Pyran-4-carboxamide, 4-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-N-hydroxy-

1. Kahraman A, et al. Hepatol Res. 2009 Aug;39(8):805-13. 2. Liechti FD, et al. J Neuroinflammation. 2015 Mar 4;12:43.

计算器

产品手册

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