CP21R7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种高亲和力、选择性 GSK3β 抑制剂，可激活经典 Wnt 信号传导。

A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling; promotes rapid and efficient differentiation of human pluripotent stem cells (hPSCs) into vascular endothelial and smooth muscle cells.(In Vitro):CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.

CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.

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CP21

PI3K/Akt/mTOR signaling

GSK-3

GSK-3β

Other Indications

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125314-13-8

317.3413

C19H15N3O2

>98% (HPLC)

DMSO: ≥ 32 mg/mL

O=C(C(C1=CC=CC(N)=C1)=C2C3=CN(C)C4=C3C=CC=C4)NC2=O

1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-

(-20℃)

With Ice Pack

≥ 2 years