CNX-1351 ( CNX1351 | CNX 1351 | CNX-1351 )

产品货号. M17234 CAS No. 1276105-89-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CNX-1351
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CNX-1351 是一种有效的异构体选择性靶向共价 PI3Kα 抑制剂。
产品描述

CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20?400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
体外实验

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体内实验

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同义词

CNX1351 | CNX 1351 | CNX-1351
通路

Others
靶点

Other Targets
受体

PI3Kα
研究领域

Cancer
适应症

——

CAS Number

1276105-89-5
分子量

573.71
分子式

C30H35N7O3S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 21.8 mg/mL. 38.00 mM
SMILES

C1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
化学全称

1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione

1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.

计算器

产品手册

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