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CK-2127107

CAS No. 1345410-31-2

CK-2127107 ( CK-107;Reldesemtiv )

产品货号. M11384 CAS No. 1345410-31-2

CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3216 有现货
10MG ¥4771 有现货
25MG ¥7655 有现货
50MG ¥10368 有现货
100MG ¥14013 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CK-2127107
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
  • 产品描述
    CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical
  • 同义词
    CK-107;Reldesemtiv
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Neurological Disease
  • 适应症
    Spinal Muscular Atrophy(SMA)

化学信息

  • CAS Number
    1345410-31-2
  • 分子量
    384.39
  • 分子式
    C19H18F2N6O
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
  • 化学全称
    1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
产品手册
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