CK-2127107
CAS No. 1345410-31-2
CK-2127107 ( CK-107;Reldesemtiv )
产品货号. M11384 CAS No. 1345410-31-2
CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3216 | 有现货 |
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10MG | ¥4771 | 有现货 |
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25MG | ¥7655 | 有现货 |
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50MG | ¥10368 | 有现货 |
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100MG | ¥14013 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CK-2127107
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
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产品描述CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical
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同义词CK-107;Reldesemtiv
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Neurological Disease
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适应症Spinal Muscular Atrophy(SMA)
化学信息
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CAS Number1345410-31-2
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分子量384.39
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分子式C19H18F2N6O
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
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化学全称1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
产品手册
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