CK-2127107 ( CK-107 | Reldesemtiv )

产品货号. M11384 CAS No. 1345410-31-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CK-2127107
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CK-2127107(CK-107, Reldesemtiv) 是一种新型口服活性快速骨骼肌肌钙蛋白激活剂，选择性激活快速骨骼肌原纤维，EC50 为 3.4 uM。
产品描述

CK-2127107(CK-107, Reldesemtiv)?is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical.
体外实验

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体内实验

Animal Model:Female Sprague-Dawley rats (Sham and left anterior descending coronary artery (LAD) heart failure (LAD-HF)) Dosage:10 mg/kg Administration:p.o.Result:Increased performance time by approximately 150% in LAD-HF rats (116±22 versus 283±47 seconds).
同义词

CK-107 | Reldesemtiv
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Neurological Disease
适应症

Spinal Muscular Atrophy(SMA)

CAS Number

1345410-31-2
分子量

384.391
分子式

C19H18F2N6O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 250 mg/mL (650.40 mM)
SMILES

O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
化学全称

1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide