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CITCO

CAS No. 338404-52-7

CITCO ( —— )

产品货号. M24287 CAS No. 338404-52-7

CITCO 抑制脑肿瘤干细胞 (BTSC) 的生长和扩增,EC50 为 49 nM 超过孕烷 X 受体 (PXR),对其他核受体没有活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥462 有现货
10MG ¥737 有现货
25MG ¥1345 有现货
50MG ¥2155 有现货
100MG ¥3216 有现货
200MG ¥4836 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CITCO
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CITCO 抑制脑肿瘤干细胞 (BTSC) 的生长和扩增,EC50 为 49 nM 超过孕烷 X 受体 (PXR),对其他核受体没有活性。
  • 产品描述
    CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49?nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it also is a selective Constitutive androstane receptor (CAR) agonist.
  • 体外实验
    CITCO (1-50 μM; 48?hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (2.5, 5?μM; 48?hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes. CITCO (2.5-10?μM; 48?hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (0-25?μM; 48?hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly. Cell Proliferation Assay Cell Line:T98G, U87MG, DB29 and DB33 human glioma cells, astrocytes Concentration:1, 2.5, 5, 10, 25, 50 μM Incubation Time:48?hours Result:Resulted in a dose-dependent inhibition of viable cell count and proliferation.Cell Cycle Analysis Cell Line:The T98G, U87MG, DB29 and DB33 glioma cells Concentration:2.5, 5?μM Incubation Time:48?hours Result:Induced cell cycle arrest differentially in different BTSCs in culture.Apoptosis Analysis Cell Line:The T98G, U87MG, DB29 and DB33 glioma cells Concentration:2.5, 5 or 10?μM Incubation Time:48?hours Result:Increased the levels of Annexin V-positive apoptotic cells in dose dependently. Western Blot Analysis Cell Line:T98G, U87MG, DB29 and DB33 glioma cells Concentration:0 to 25?μM Incubation Time:48?hours Result:The T98G, U87MG glioma and BTSCs expressed very low levels of CAR protein that increased significantly.
  • 体内实验
    CITCO (intraperitoneal; on days 22, 24, 26, 30 and 36) with 25?μg results a significant decrease in tumour growth, which further decreases to an undetectable level after treatment with 100?μg CITCO . Animal Model:Six- to eight-week-old male athymic nude mice Dosage:25 or 100?μg Administration:Intraperitoneal; on days 22, 24, 26, 30 and 36 Result:Decreased tumour growth.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    CAR|PXR
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    338404-52-7
  • 分子量
    436.74
  • 分子式
    C19H12Cl3N3OS
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:soluble; H2O:insoluble
  • SMILES
    Clc(cc1)ccc1-c1c(/C=N/OCc(cc2)cc(Cl)c2Cl)n(ccs2)c2n1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Chakraborty S, et al. Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells. Br J Cancer. 2011 Feb 1;104(3):448-59.
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