
CITCO
CAS No. 338404-52-7
CITCO ( —— )
产品货号. M24287 CAS No. 338404-52-7
CITCO 抑制脑肿瘤干细胞 (BTSC) 的生长和扩增,EC50 为 49 nM 超过孕烷 X 受体 (PXR),对其他核受体没有活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥462 | 有现货 |
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10MG | ¥737 | 有现货 |
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25MG | ¥1345 | 有现货 |
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50MG | ¥2155 | 有现货 |
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100MG | ¥3216 | 有现货 |
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200MG | ¥4836 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CITCO
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CITCO 抑制脑肿瘤干细胞 (BTSC) 的生长和扩增,EC50 为 49 nM 超过孕烷 X 受体 (PXR),对其他核受体没有活性。
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产品描述CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49?nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it also is a selective Constitutive androstane receptor (CAR) agonist.
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体外实验CITCO (1-50 μM; 48?hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (2.5, 5?μM; 48?hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes. CITCO (2.5-10?μM; 48?hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (0-25?μM; 48?hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly. Cell Proliferation Assay Cell Line:T98G, U87MG, DB29 and DB33 human glioma cells, astrocytes Concentration:1, 2.5, 5, 10, 25, 50 μM Incubation Time:48?hours Result:Resulted in a dose-dependent inhibition of viable cell count and proliferation.Cell Cycle Analysis Cell Line:The T98G, U87MG, DB29 and DB33 glioma cells Concentration:2.5, 5?μM Incubation Time:48?hours Result:Induced cell cycle arrest differentially in different BTSCs in culture.Apoptosis Analysis Cell Line:The T98G, U87MG, DB29 and DB33 glioma cells Concentration:2.5, 5 or 10?μM Incubation Time:48?hours Result:Increased the levels of Annexin V-positive apoptotic cells in dose dependently. Western Blot Analysis Cell Line:T98G, U87MG, DB29 and DB33 glioma cells Concentration:0 to 25?μM Incubation Time:48?hours Result:The T98G, U87MG glioma and BTSCs expressed very low levels of CAR protein that increased significantly.
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体内实验CITCO (intraperitoneal; on days 22, 24, 26, 30 and 36) with 25?μg results a significant decrease in tumour growth, which further decreases to an undetectable level after treatment with 100?μg CITCO . Animal Model:Six- to eight-week-old male athymic nude mice Dosage:25 or 100?μg Administration:Intraperitoneal; on days 22, 24, 26, 30 and 36 Result:Decreased tumour growth.
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同义词——
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通路Others
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靶点Other Targets
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受体CAR|PXR
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研究领域——
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适应症——
化学信息
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CAS Number338404-52-7
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分子量436.74
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分子式C19H12Cl3N3OS
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纯度>98% (HPLC)
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溶解度DMSO:soluble; H2O:insoluble
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SMILESClc(cc1)ccc1-c1c(/C=N/OCc(cc2)cc(Cl)c2Cl)n(ccs2)c2n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chakraborty S, et al. Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells. Br J Cancer. 2011 Feb 1;104(3):448-59.
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