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CINPA1
CAS No. 102636-74-8
CINPA1 ( CINPA 1 | CINPA-1 )
产品货号. M26650 CAS No. 102636-74-8
CINPA1 是一种组成型雄甾烷受体 (CAR) 的选择性抑制剂，对于 CAR 介导的转录的 IC50 为 70 nM。 CINPA1可用于CAR功能的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥324 | 有现货 |
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| 5MG | ￥518 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CINPA1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CINPA1 是一种组成型雄甾烷受体 (CAR) 的选择性抑制剂，对于 CAR 介导的转录的 IC50 为 70 nM。 CINPA1可用于CAR功能的研究。
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产品描述CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.(In Vitro):CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM. CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed and it efficiently inhibits CAR-LBD interaction with the coactivator peptide. CINPA1 (1μM) inhibits CAR-mediated transactivation without activating the pregnane X receptor (PXR) in HepG2 cells. In mammalian two-hybrid assays, CINPA1 increases the corepressor and reduces coactivator interaction with the CAR ligand-binding domain. In chromatin immunoprecipitation assays, CINPA1 disrupts CAR binding to the promoter regions of target genes.
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体外实验——
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体内实验——
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同义词CINPA 1 | CINPA-1
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通路Others
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靶点Other Targets
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受体AMPAR
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研究领域——
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适应症——
化学信息
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CAS Number102636-74-8
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分子量395.503
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分子式C23H29N3O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (632.13 mM)
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SMILESCCOC(=O)Nc1ccc2CCc3ccccc3N(C(=O)CN(CC)CC)c2c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.
