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CI-994
CAS No. 112522-64-2
CI-994 ( Acetyldinaline;Tacedinaline;PD-123654;Goe-5549 )
产品货号. M10439 CAS No. 112522-64-2
A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥348 | 有现货 |
|
| 50MG | ￥535 | 有现货 |
|
| 100MG | ￥786 | 有现货 |
|
| 200MG | ￥1385 | 有现货 |
|
| 500MG | ￥2989 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CI-994
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
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产品描述A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively; show no significant inhibitory activity against HDAC8 (IC50>20 uM); reduces S phase level and increases apoptosis in A-549 and LX-1 cells; demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.Breast Cancer Phase 2 Discontinued
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同义词Acetyldinaline;Tacedinaline;PD-123654;Goe-5549
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC2;HDAC3
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研究领域Cancer
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适应症Breast Cancer
化学信息
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CAS Number112522-64-2
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分子量269.30
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分子式C15H15N3O2
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 58 mg/mL
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SMILESO=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2
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化学全称Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
产品手册
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