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CI-1044
CAS No. 197894-84-1
CI-1044 ( CI1044 )
产品货号. M13094 CAS No. 197894-84-1
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2406 | 有现货 |
|
| 50MG | ￥11016 | 有现货 |
|
| 100MG | ￥15066 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CI-1044
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM.
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产品描述CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities; exhibits efficient in vitro inhibition of TNFα release from hPBMC and hWB with IC50 of 0.34 and 0.84 uM, respectively; exhibits potent in vivo activity in antigen-induced eosinophil recruitment in rats (ED50=3.2 mg/kg, p.o.).Asthma Phase 1 Clinical
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同义词CI1044
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Inflammation/Immunology
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适应症Asthma
化学信息
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CAS Number197894-84-1
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分子量397.44
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分子式C23H19N5O2
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纯度>98% (HPLC)
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溶解度DMSO : 125 mg/mL 314.52 mM
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SMILESNc1cc2CCN3C(=O)[C@H](NC(=O)c4cccnc4)N=C(c5ccccc5)c(c1)c23
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化学全称(R)-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)nicotinamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Burnouf C, et al. J Med Chem. 2000 Dec 14;43(25):4850-67.
2. Ouagued M, et al. Pulm Pharmacol Ther. 2005;18(1):49-54.
3. Hanton G, et al. Toxicol Lett. 2008 Jun 10;179(1):15-22.
2. Ouagued M, et al. Pulm Pharmacol Ther. 2005;18(1):49-54.
3. Hanton G, et al. Toxicol Lett. 2008 Jun 10;179(1):15-22.
产品手册
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