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CHK1-IN-3
CAS No. 2097252-39-4
CHK1-IN-3 ( —— )
产品货号. M26107 CAS No. 2097252-39-4
CHK1-IN-2 是检查点激酶 1 的抑制剂 (CHK1；IC50: 0.4 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2373 | 有现货 |
|
| 5MG | ￥3621 | 有现货 |
|
| 10MG | ￥5338 | 有现货 |
|
| 25MG | ￥7995 | 有现货 |
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| 50MG | ￥11178 | 有现货 |
|
| 100MG | ￥15309 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHK1-IN-3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CHK1-IN-2 是检查点激酶 1 的抑制剂 (CHK1；IC50: 0.4 nM)。
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产品描述CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).(In Vitro):CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 μM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM).(In Vivo):In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected.
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体外实验CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displays low affinity for hERG (IC50 > 40 μM).
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体内实验CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected.
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同义词——
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通路Angiogenesis
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靶点Chk
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受体Alkyl-Chain
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研究领域——
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适应症——
化学信息
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CAS Number2097252-39-4
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分子量405.466
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分子式C20H23N9O
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纯度>98% (HPLC)
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溶解度——
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SMILESCNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
