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CHIR-99021
CAS No. 252917-06-9
CHIR-99021 ( CT99021 | CHIR99021 | CHIR 99021 | CT-99021 )
产品货号. M13747 CAS No. 252917-06-9
一种有效的特异性 GSK-3 抑制剂，对 GSK3β 和 GSK3α 的 IC50 分别为 5 nM 和 10 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥324 | 有现货 |
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| 5MG | ￥494 | 有现货 |
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| 10MG | ￥721 | 有现货 |
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| 25MG | ￥1401 | 有现货 |
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| 50MG | ￥2179 | 有现货 |
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| 100MG | ￥3475 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHIR-99021
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的特异性 GSK-3 抑制剂，对 GSK3β 和 GSK3α 的 IC50 分别为 5 nM 和 10 nM。
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产品描述A potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively; mimics Wnt signaling in preadipocytes, stabilizes free cytosolic beta-catenin and inhibits adipogenesis by blocking induction of C/EBPα and PPARγ; potentiates insulin activation of glucose transport and utilization in vitro and in vivo; also widely used for stem cell differentiation and naive stem cell generation.(In Vitro):Laduviglusib (1-10 μM, 3 days) reduces the viability of the ES-D3 cells with an IC50 of 4.9 μM.Laduviglusib (5 μM, 48 h) activates the canonical Wnt-pathway in ES-D3 cells and ES-CCE cells.Laduviglusib (3 μM, 4 days) inhibits ES cell differentiation into neural cells.Laduviglusib (1 μM, 2 weeks) inhibits adipogenesis by blocking induction of C/EBPα and PPARγ in 3T3-L1 preadipocytes.Laduviglusib (2.5 μM, 24 h) protects Lgr5+ cells against radiation-induced apoptosis.(In Vivo):Laduviglusib (30 mg/kg, p.o ) rapidly lowers plasma glucose.Laduviglusib (2 mg/kg, i.p.) protects mice against radiation-induced lethal GI injury.
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体外实验Laduviglusib (GMP) (20 μM, 21 days) transdifferentiates mouse fibroblasts to neurons (determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells).Laduviglusib (GMP) (3-5?μM, 2 days) induces somatic cells differentiation of pluripotent stem (PS) cells (the detailed method refers to the reference).Laduviglusib (GMP) (12?μM, 5 days) converts human fibroblasts (HFF) into functional cardiomyocytes.Laduviglusib (GMP) (3 μM, 4 days, hESCs) activates the canonical WNT signaling pathway, confirmed by β-catenin translocation into the nucleus.Laduviglusib (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells led by RepSox (GMP) (HY-13012G) together with Forskolin (HY-15371).Laduviglusib (GMP) (5 μM, 1 day) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC).
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体内实验——
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同义词CT99021 | CHIR99021 | CHIR 99021 | CT-99021
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通路PI3K/Akt/mTOR signaling
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靶点GSK-3
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受体GSK-3α|GSK-3β
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研究领域Cancer
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适应症——
化学信息
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CAS Number252917-06-9
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分子量465.3379
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分子式C22H18Cl2N8
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 5.1 mg/mL
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SMILESCC1=CN=C(N1)C1=CN=C(NCCNC2=NC=C(C=C2)C#N)N=C1C1=C(Cl)C=C(Cl)C=C1
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化学全称3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ying QL, et al. Nature. 2008 May 22;453(7194):519-23.
2. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.
3. Bennett CN, et al. J Biol Chem. 2002 Aug 23;277(34):30998-1004.
4. Li W, et al. Stem Cells. 2009 Dec;27(12):2992-3000.
产品手册
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