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CHIR-090

CAS No. 728865-23-4

CHIR-090 ( CHIR-090; CHIR 090; CHIR090 )

产品货号. M17583 CAS No. 728865-23-4

CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.

纯度: 97%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥786 有现货
10MG ¥1272 有现货
25MG ¥2697 有现货
50MG ¥4317 有现货
100MG ¥6261 有现货
500MG ¥12798 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CHIR-090
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.
  • 产品描述
    CHIR-090 is a very potent and selective LpxC inhibitor. CHIR-090 has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli. CHIR-090 is also a two-step slow, tight-binding inhibitor of E. coli LpxC with Ki = 4.0 nM, Ki* = 0.5 nM, k5 = 1.9 min-1, and k6 = 0.18 min-1. CHIR-090 at low nanomolar levels inhibits LpxC orthologues from diverse Gram-negative pathogens, including P. aeruginosa, Neisseria meningitidis, and Helicobacter pylori. In contrast, CHIR-090 is a relatively weak competitive and conventional inhibitor (lacking slow, tight-binding kinetics) of LpxC from Rhizobium leguminosarum (Ki = 340 nM), a Gram-negative plant endosymbiont that is resistant to this compound. CHIR-090 is an excellent lead for the further development of new antibiotics targeting the lipid A pathway.
  • 同义词
    CHIR-090; CHIR 090; CHIR090
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Escherichia coli LpxC
  • 研究领域
    Infection
  • 适应症
    ——

化学信息

  • CAS Number
    728865-23-4
  • 分子量
    437.19
  • 分子式
    C24H27N3O5
  • 纯度
    97%
  • 溶解度
    DMSO : ≥ 30 mg/mL; 68.57 mM
  • SMILES
    ONC(=O)[C@@H](NC(=O)c1ccc(cc1)C#Cc1ccc(cc1)CN1CCOCC1)[C@@H](C)O
  • 化学全称
    N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Barb AW, et al. Biochemistry. 2007 Mar 27;46(12):3793-802. Epub 2007 Mar 3.
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