CHIR-090
CAS No. 728865-23-4
CHIR-090 ( CHIR-090; CHIR 090; CHIR090 )
产品货号. M17583 CAS No. 728865-23-4
CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.
纯度: 97%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
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10MG | ¥1272 | 有现货 |
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25MG | ¥2697 | 有现货 |
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50MG | ¥4317 | 有现货 |
|
100MG | ¥6261 | 有现货 |
|
500MG | ¥12798 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHIR-090
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.
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产品描述CHIR-090 is a very potent and selective LpxC inhibitor. CHIR-090 has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli. CHIR-090 is also a two-step slow, tight-binding inhibitor of E. coli LpxC with Ki = 4.0 nM, Ki* = 0.5 nM, k5 = 1.9 min-1, and k6 = 0.18 min-1. CHIR-090 at low nanomolar levels inhibits LpxC orthologues from diverse Gram-negative pathogens, including P. aeruginosa, Neisseria meningitidis, and Helicobacter pylori. In contrast, CHIR-090 is a relatively weak competitive and conventional inhibitor (lacking slow, tight-binding kinetics) of LpxC from Rhizobium leguminosarum (Ki = 340 nM), a Gram-negative plant endosymbiont that is resistant to this compound. CHIR-090 is an excellent lead for the further development of new antibiotics targeting the lipid A pathway.
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同义词CHIR-090; CHIR 090; CHIR090
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通路Others
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靶点Other Targets
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受体Escherichia coli LpxC
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研究领域Infection
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适应症——
化学信息
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CAS Number728865-23-4
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分子量437.19
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分子式C24H27N3O5
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纯度97%
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溶解度DMSO : ≥ 30 mg/mL; 68.57 mM
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SMILESONC(=O)[C@@H](NC(=O)c1ccc(cc1)C#Cc1ccc(cc1)CN1CCOCC1)[C@@H](C)O
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化学全称N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Barb AW, et al. Biochemistry. 2007 Mar 27;46(12):3793-802. Epub 2007 Mar 3.
产品手册
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