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CH5138303
CAS No. 959763-06-5
CH5138303 ( CH5138303 | CH-5138303 | CH 5138303 )
产品货号. M19285 CAS No. 959763-06-5
CH5138303 是一种口服 Hsp90 抑制剂，Kd 为 0.48 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1823 | 有现货 |
|
| 10MG | ￥2916 | 有现货 |
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| 25MG | ￥5257 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CH5138303
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CH5138303 是一种口服 Hsp90 抑制剂，Kd 为 0.48 nM。
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产品描述CH5138303 is a novel and potent HSP90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd=0.52nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50=0.098μM, NCI-N87 IC50=0.066μM) and also displayed high oral bioavailability in mice (F=44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition=136%).
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体外实验When used in combination with FLC, CH5138303 shows antifungal activitiy against azole-resistant C. albicans, with a FICI (fractional inhibitory concentration index) of 0.500.
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体内实验CH5138303 (SCID mice bearing NCI-N87 cells, 0-50 mg/kg, Orally, once daily for 11 days) shows potent antitumor efficacy with TGI (tumor growth inhibition) of 136% and a median effective dose (ED50) of 3.9 mg/kg without significant loss of body weight.
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同义词CH5138303 | CH-5138303 | CH 5138303
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通路Endocrinology/Hormones
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靶点Reductase
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受体HSP90α
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研究领域Cancer
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适应症——
化学信息
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CAS Number959763-06-5
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分子量415.9
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分子式C19H18ClN5O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESNC(=O)CCCSC1=NC(N)=NC(=N1)C1=C(Cl)C=C2COCC3=CC=CC1=C23
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化学全称4-((4-amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Suda A, et al. Bioorg Med Chem. 2014, 22(2), 892-905.
产品手册
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