CH5132799
CAS No. 1007207-67-1
CH5132799 ( CH5132799; CH-5132799; PA799; PA-799. )
产品货号. M17113 CAS No. 1007207-67-1
CH5132799 has been used in trials studying the treatment of Solid Tumors.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥713 | 有现货 |
|
5MG | ¥1191 | 有现货 |
|
10MG | ¥1936 | 有现货 |
|
25MG | ¥3588 | 有现货 |
|
50MG | ¥5306 | 有现货 |
|
100MG | ¥7549 | 有现货 |
|
500MG | ¥15228 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称CH5132799
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述CH5132799 has been used in trials studying the treatment of Solid Tumors.
-
产品描述CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. CH5132799 selectively inhibited class I PI3Ks and PI3Kα mutants in in vitro kinase assays. Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.
-
同义词CH5132799; CH-5132799; PA799; PA-799.
-
通路Others
-
靶点Other Targets
-
受体mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1007207-67-1
-
分子量377.42
-
分子式C15H19N7O3S
-
纯度98%
-
溶解度DMSO : 4.55 mg/mL 12.06 mM;H2O : < 0.1 mg/mL
-
SMILESCS(=O)(=O)N1CCc2c(nc(nc12)N1CCOCC1)c1cnc(N)nc1
-
化学全称5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Tanaka H, et al, Clin Y Res, 2011, 17(10), 3272-3281.
产品手册
关联产品
-
Spirostan-3-ol
Spirostan-3-ol is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis.
-
Apoptozole
Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.
-
Neoechinulin A
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways.