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CH5132799

CAS No. 1007207-67-1

CH5132799 ( CH5132799; CH-5132799; PA799; PA-799. )

产品货号. M17113 CAS No. 1007207-67-1

CH5132799 has been used in trials studying the treatment of Solid Tumors.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥713 有现货
5MG ¥1191 有现货
10MG ¥1936 有现货
25MG ¥3588 有现货
50MG ¥5306 有现货
100MG ¥7549 有现货
500MG ¥15228 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CH5132799
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CH5132799 has been used in trials studying the treatment of Solid Tumors.
  • 产品描述
    CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. CH5132799 selectively inhibited class I PI3Ks and PI3Kα mutants in in vitro kinase assays. Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.
  • 同义词
    CH5132799; CH-5132799; PA799; PA-799.
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1007207-67-1
  • 分子量
    377.42
  • 分子式
    C15H19N7O3S
  • 纯度
    98%
  • 溶解度
    DMSO : 4.55 mg/mL 12.06 mM;H2O : < 0.1 mg/mL
  • SMILES
    CS(=O)(=O)N1CCc2c(nc(nc12)N1CCOCC1)c1cnc(N)nc1
  • 化学全称
    5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Tanaka H, et al, Clin Y Res, 2011, 17(10), 3272-3281.
产品手册
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