CGP-049090

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种小分子，可特异性抑制结肠癌细胞系中 β-catenin/LEF1 转录复合物的相互作用。

A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines; efficiently kills CLL cells with LC50 of <1 uM, without significantly toxcity for normal B cells; is well tolerated and exhibits tumor inhibition in in vivo studies.

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively).Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ? S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells. Cell Viability Assay Cell Line:Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7 Concentration:0 μM, 1 μM, 2 μM, 3 μMIncubation Time:24 hours Result:Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

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CGP049090 | Cercosporin

Wnt/Notch/Hedgehog

Beta-catenin

Beta-catenin

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35082-49-6

534.517

C29H26O10

>98% (HPLC)

In Vitro:?DMSO : ≥ 10 mg/mL (18.71 mM)

CC(CC1=C2C3=C(C(=C(C4=C3C5=C6C2=C(C(=O)C=C6OCOC5=CC4=O)C(=C1OC)O)O)OC)CC(C)O)O

6,12-dihydroxy-8,9-bis((R)-2-hydroxypropyl)-7,10-dimethoxyperyleno[1,12-def][1,3]dioxepine-5,11-dione

(-20℃)

With Ice Pack

≥ 2 years