CCT241736 ( CCT241736; CCT-241736; CCT 241736 )

产品货号. M17277 CAS No. 1402709-93-6

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HNMR

HPLC

MSDS

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产品名称

CCT241736
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3.
产品描述

CCT241736 is a potent and orally active and dual FLT3-Aurora inhibitor. CCT241736 has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively. CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I. In cellular assays, CCT241736 inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 and MV-4;11 with EC50 values of 0.1 and 0.27
同义词

CCT241736; CCT-241736; CCT 241736
通路

GPCR/G Protein
靶点

Dopamine Receptor
受体

FLT3;Aurora Kinase
研究领域

——
适应症

——

CAS Number

1402709-93-6
分子量

456.37
分子式

C22H23Cl2N7
纯度

98%
溶解度

DMSO : 75 mg/mL 164.34 mM; H2O : < 0.1 mg/mL
SMILES

Cc5nn(C)cc5c3nc4ncc(Cl)c(N2CCN(Cc1ccc(Cl)cc1)CC2)c4n3
化学全称

6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine

1.Bavetsias V,etal. J Med Chem. 2012 Oct 25;55(20):8721-34.

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