CCI-006
CAS No. 292053-42-0
CCI-006 ( —— )
产品货号. M22449 CAS No. 292053-42-0
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1158 | 有现货 |
|
5MG | ¥2001 | 有现货 |
|
10MG | ¥3143 | 有现货 |
|
25MG | ¥5249 | 有现货 |
|
50MG | ¥7501 | 有现货 |
|
100MG | ¥10206 | 有现货 |
|
500MG | ¥20412 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称CCI-006
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
-
产品描述CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Mitochondria
-
研究领域——
-
适应症——
化学信息
-
CAS Number292053-42-0
-
分子量332.33
-
分子式C15H12N2O5S
-
纯度>98% (HPLC)
-
溶解度DMSO:83.33 mg/mL (250.74 mM)
-
SMILESCOC(=O)C(\C#N)=C\c1ccc(o1)-c1ccc(cc1)S(N)(=O)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
产品手册
关联产品
-
JAG-1, scrambled
This peptide is a scrambled sequence of JAG-1(188-204).
-
PF-00835231
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials.
-
Edonerpic maleate
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).