CAY-10603 ( CAY10603 )

产品货号. M10225 CAS No. 1045792-66-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CAY-10603
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM.
产品描述

A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM; 200-fold less potent for HDAC3 (IC50=0.42 nM) and no inhibition on HDAC1/2/8/10 (IC50> 100 nM); downregulates the levels of EGFR protein and synergizes with gefitinib to induce apoptosis of the lung adenocarcinoma cell lines.
同义词

CAY10603
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC1;HDAC6
研究领域

Cancer
适应症

——

CAS Number

1045792-66-2
分子量

446.50
分子式

C22H30N4O6
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1
化学全称

Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester

1. Kozikowski AP, et al. J Med Chem. 2008 Aug 14;51(15):4370-3.
2. Wang Z, et al. Oncol Rep. 2016 Jul;36(1):589-97.

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产品手册

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