CAY-10603
CAS No. 1045792-66-2
CAY-10603 ( CAY10603 )
产品货号. M10225 CAS No. 1045792-66-2
A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥608 | 有现货 |
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5MG | ¥786 | 有现货 |
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10MG | ¥1401 | 有现货 |
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25MG | ¥2616 | 有现货 |
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50MG | ¥4431 | 有现货 |
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100MG | ¥6383 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CAY-10603
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM.
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产品描述A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM; 200-fold less potent for HDAC3 (IC50=0.42 nM) and no inhibition on HDAC1/2/8/10 (IC50> 100 nM); downregulates the levels of EGFR protein and synergizes with gefitinib to induce apoptosis of the lung adenocarcinoma cell lines.
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同义词CAY10603
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC6
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研究领域Cancer
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适应症——
化学信息
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CAS Number1045792-66-2
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分子量446.50
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分子式C22H30N4O6
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1
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化学全称Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kozikowski AP, et al. J Med Chem. 2008 Aug 14;51(15):4370-3.
2. Wang Z, et al. Oncol Rep. 2016 Jul;36(1):589-97.
2. Wang Z, et al. Oncol Rep. 2016 Jul;36(1):589-97.
产品手册
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