Brazilin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Brazilin 具有癌症预防作用，可能通过 c-Fos 介导的肿瘤细胞特异性信号通路抑制 T24 细胞生长并引发细胞死亡。

Brazilin exhibits anti-hepatotoxic, antiplatelet effects. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific signaling pathway. Brazilin has anti-inflammatory property, can suppress mastitis and high glucose-induced vascular inflammatory process related with the inhibition of oxidative stress, CAMs expression, and NF-κB activation in HUVEC; may be useful to treat chronic inflammatory disorders including rheumatoid arthritis.

Cell Viability Assay Cell Line:PC12 cell line Concentration:10, 20 μM Incubation Time:1 h Result:Attenuated 200 μM H2O2-induced decrease in cell viability at the concentration of 10 μM and 20 μM.(47.83 and 91.51% of the control value, respectively)

Animal Model:Chronic mild stress (CMS) mice model Dosage:10 mg/kg.Administration:Intraperitoneally injected (i.p.), once a day for 28 d. Result:Decreased the prolonged latency to feeding significantly.

Brazilin

Membrane Transporter/Ion Channel

AMPK

Others

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——

474-07-7

286.28

C16H14O5

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (116.42 mM)

C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4)O)O)O)O

(6aS,11bR)-7,11b-Dihydro-6H-indeno[2,1-c]chromene-3,6a,9,10-tetrol

(-20℃)

With Ice Pack

≥ 2 years