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Bractoppin
CAS No. 2290527-07-8
Bractoppin ( —— )
产品货号. M24041 CAS No. 2290527-07-8
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥632 | 有现货 |
|
| 5MG | ￥1021 | 有现货 |
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| 10MG | ￥1677 | 有现货 |
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| 25MG | ￥3629 | 有现货 |
|
| 50MG | ￥5330 | 有现货 |
|
| 100MG | ￥7598 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Bractoppin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro.
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产品描述Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2290527-07-8
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分子量414.5
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分子式C25H23FN4O
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESO=C(N1CCN(CC2=CC=CC=C2F)CC1)C3=CC=C4NC(C5=CC=CC=C5)=NC4=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Periasamy J , Kurdekar V , Jasti S , et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling[J]. Cell Chemical Biology, 2018:S245194561830076X.
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