Bobcat339 ( Bobcat 339 )

产品货号. M13625 CAS No. 2280037-51-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Bobcat339
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Bobcat339 (Bobcat 339) 是一种新型的基于胞嘧啶的 TET 酶抑制剂，IC50 为 33 uM (TET1) 和 73 uM (TET2)。
产品描述

Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a; Bobcat339 is a useful tool for investigation of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.
体外实验

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.
体内实验

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同义词

Bobcat 339
通路

Chromatin/Epigenetic
靶点

DNMT
受体

TET1|TET2
研究领域

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适应症

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CAS Number

2280037-51-4
分子量

297.742
分子式

C16H12ClN3O
纯度

>98% (HPLC)
溶解度

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

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化学全称

1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one