Bergaptol ( 5-Hydroxypsoralen | 4-Hydroxybergapten )

产品货号. M18628 CAS No. 486-60-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Bergaptol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Bergaptol 是 CYP3A4 酶脱苄基活性的有效抑制剂。
产品描述

Bergaptol shows very good radical scavenging activity. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
体外实验

Western Blot Analysis Cell Line:LPS-induced RAW264.7 cells Concentration:50 μg/mL Incubation Time:24 h Result:Inhibited JNK phosphorylation and NF-κB activation.Inhibited NF-κB P65 translocation from the cytosol to nucleus.
体内实验

Animal Model:LPS (40 μg/kg, i.c.v.)-treated miceDosage:10-40 mg/kg Administration:i.p., once a day for two week Result:Reduced LPS-induced fixation and cleavage of neuronal nuclei in the CA1 region of the hippocampus (H&E staining).Increasead the dendritic spine density of mice.Inhibited LPS-induced neuroinflammation.
同义词

5-Hydroxypsoralen | 4-Hydroxybergapten
通路

Others
靶点

Other Targets
受体

Others
研究领域

Cancer
适应症

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计算器

产品手册

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