BecloMethasone ( Beclometasone )

产品货号. M22752 CAS No. 4419-39-0

BecloMethasone 是一种原型糖皮质激素受体激动剂。它局部用作抗炎剂，并以气雾剂形式用于治疗哮喘。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
10MG	￥332	有现货
25MG	￥543	有现货
50MG	￥834	有现货
100MG	￥1191	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

BecloMethasone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BecloMethasone 是一种原型糖皮质激素受体激动剂。它局部用作抗炎剂，并以气雾剂形式用于治疗哮喘。
产品描述

BecloMethasone is a prototype glucocorticoid receptor agonist.?It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.(In Vitro):An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.
体外实验

An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.
体内实验

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同义词

Beclometasone
通路

Others
靶点

Other Targets
受体

glucocorticoid receptor
研究领域

Respiratory system
适应症

Asthma

化学信息

CAS Number

4419-39-0
分子量

408.92
分子式

C22H29ClO5
纯度

>98% (HPLC)
溶解度

DMSO:31 mg/mL(75.81 mM)
SMILES

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45.

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