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Bavachin
CAS No. 19879-32-4
Bavachin ( —— )
产品货号. M18197 CAS No. 19879-32-4
Bavachin 是一种植物雌激素,可激活雌激素受体 ERα 和 ERβ。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥529 | 有现货 |
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5MG | ¥794 | 有现货 |
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10MG | ¥1411 | 有现货 |
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25MG | ¥2867 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Bavachin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Bavachin 是一种植物雌激素,可激活雌激素受体 ERα 和 ERβ。
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产品描述Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
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体外实验Bavachin significantly inhibits melanin synthesis and TYR activity. Bavachin (10 μM) inhibits the expression of TYR and JNK proteins, and the expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2 mRNA in A375 cells. ICI182780 and U0126 cAN significantly reverse the bavachin treatment on the protein expression levels and the mRNA expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2. Bavachin accumulates lipid in a dose dependent manner in ORO staining experiments. Bavachin significantly increases the growth of preadipoctye at 10 μM compared with the control cells in MTT assay. Bavachin also increases BrdU incorporation into newly synthesized DNA during pre-adipocyte proliferation. BrdU incorporation is enhanced by insulin and further enhanced by co-treatment with insulin and bavachin at 2 and 10 μM. Bavachin activates adipogenic factors and increases PPARγ transcriptional activity in differentiated adipocytes. Bavachin enhances insulin-stimulated glucose uptake through GLUT4 translocation via Akt and AMPK pathway. BVN significantly increases both hMAO-A and hMAO-B activities. Bavachin shows ER ligand binding activity in competitive displacement of [3H] E2 from recombinant ER. The estrogenic activity of bavachin is characterized in a transient transfection system using ERα or ERβ and estrogen-responsive luciferase plasmids in CV-1 cells with an EC50 of 320 nM and 680 nM, respectively. Bavachin increases the mRNA levels of estrogen-responsive genes such as pS2 and PR, and decreases the protein level of ERα by proteasomal pathway.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体ERα| ERβ
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研究领域Cancer
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适应症——
化学信息
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CAS Number19879-32-4
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分子量324.38
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分子式C20H20O4
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 150 mg/mL; 462.43 mM
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SMILES[C@H]1(CC(=O)c2c(O1)cc(c(c2)CC=C(C)C)O)c1ccc(cc1)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Park J1,et al. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomol Ther (Seoul). 2012 Mar;20(2):183-8.
产品手册
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