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Bakuchiol
CAS No. 10309-37-2
Bakuchiol ( (S)-(+)-Bakuchiol )
产品货号. M21822 CAS No. 10309-37-2
Bakuchiol 是一种从补骨脂 (Psoralea corylifolia L) 种子中分离出来的植物雌激素；具有抗肿瘤作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥918 | 有现货 |
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| 10MG | ￥1332 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Bakuchiol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Bakuchiol 是一种从补骨脂 (Psoralea corylifolia L) 种子中分离出来的植物雌激素；具有抗肿瘤作用。
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产品描述Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects. IC50 value: Target: in vitro: Bakuchiol reduced mitochondrial membrane potential (Psim) of cells in a concentration- and time-dependent manner, showing a more potent effect than that of resveratrol. S phase arrest, caspase 9/3 activaton, p53 and Bax up-regulation, as well as Bcl-2 down-regulation were observed in bakuchiol-treated A549 cells. UGT2B7 was inhibited by the strongest intensity. The noncompetitive inhibition was demonstrated by the results obtained from Dixon plot and Lineweaver-Burk plot. The Ki value was calculated to be 10.7 μM. Bakuchiol was found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62μM to 3.89μM.
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体外实验——
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体内实验——
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同义词(S)-(+)-Bakuchiol
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通路MAPK/ERK Signaling
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靶点p38 MAPK
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number10309-37-2
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分子量256.38
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分子式C??H??O
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纯度>98% (HPLC)
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溶解度DMSO : 62.5 mg/mL (243.78 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)
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SMILESOC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)\C)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chen Z, et al. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol. 2010 Sep 25;643(2-3):170-9.
2. Xu Y, et al. In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14(3):564-9.
3. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106.
