BVT948
CAS No. 39674-97-0
BVT948 ( —— )
产品货号. M26636 CAS No. 39674-97-0
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥778 | 有现货 |
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10MG | ¥1150 | 有现货 |
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25MG | ¥1928 | 有现货 |
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50MG | ¥2859 | 有现货 |
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100MG | ¥4261 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BVT948
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.
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产品描述BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.(In Vitro):BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity). BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity.(In Vivo):Compare with vehicle-treated controls, BVT948 (BVT.948, 3 μmol/kg) significantly enhances glucose clearance from the blood stream in response to insulin.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phosphatase
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受体tryptaminic receptor
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研究领域——
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适应症——
化学信息
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CAS Number39674-97-0
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分子量241.2
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分子式C14H11NO3
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1(C)C(=O)N=C2C1=C(O)C(=O)c1ccccc21
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.L F De Oliveira, et al. Blockade by bufotenidine of the serotonin- and narcotic-analgesics-induced contraction of dog intestine in vivo. Eur J Pharmacol
产品手册
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