BTdCPU

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BTdCPU 是一种有效的血红素调节 eIF2α 激酶 (HRI) 激活剂。 BTdCPU 促进 eIF2α 磷酸化并诱导耐药细胞凋亡。

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator.?BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.

Western Blot Analysis Cell Line:MM1.S and MM1.R cells Concentration:10 μMIncubation Time:0, 4, 8 h Result:Induced phosphorylation of eIF2α and upregulated mRNA and protein levels of the pro-apoptotic protein CHOP.Western Blot Analysis Cell Line:Bone marrow mononuclear cells (MNC) from multiple myeloma (MM) patient or healthy donor Concentration:10 μM Incubation Time:0, 4, 8 h Result:Induced early expression of CHOP in MM patient cells, but not in healthy bone marrow mononuclear cells (MNC).

Animal Model:Female nude mice (mice xenograft breast tumors model).Dosage:175 mg/kg Administration:Intraperitoneal injection; single daily for 21 days Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week study.Showed good safety in mice.

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Apoptosis

PERK

eIF-2α

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1257423-87-2

339.2

C13H8Cl2N4OS

>98% (HPLC)

DMSO:250 mg/mL?(737.03 mM)

Clc1ccc(NC(=O)Nc2ccc3nnsc3c2)cc1Cl

1-(Benzo[d][123]thiadiazol-6-yl)-3-(34-dichlorophenyl)urea

(-20℃)

With Ice Pack

≥ 2 years