
BTB-1
CAS No. 86030-08-2
BTB-1 ( BTB1 | BTB 1 | BTB-1 )
产品货号. M19186 CAS No. 86030-08-2
BTB-1 是有丝分裂运动蛋白 Kif18A 的新型小分子抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥462 | 有现货 |
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10MG | ¥648 | 有现货 |
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25MG | ¥1158 | 有现货 |
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50MG | ¥1960 | 有现货 |
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100MG | ¥2900 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BTB-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BTB-1 是有丝分裂运动蛋白 Kif18A 的新型小分子抑制剂。
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产品描述BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A?’s MT-stimulated ATPase activity, with an IC50 of 1.7?–1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A?’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A?’s double functionality within mitosis and assessing for potential therapeutic utilities.
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体外实验BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner. BTB-1 shows cell toxicity with an EC50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles.
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体内实验——
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同义词BTB1 | BTB 1 | BTB-1
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通路Others
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靶点Other Targets
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受体mitotic kinesin Kif18A
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研究领域Cancer
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适应症——
化学信息
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CAS Number86030-08-2
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分子量297.71
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分子式C12H8ClNO4S
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 100 mg/mL; 335.90 mM
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SMILESO=S(=O)(c1ccc(Cl)cc1[N+](=O)[O-])c1ccccc1
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化学全称4-chloro-2-nitro-1-(phenylsulfonyl)benzene
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Catarinella M., et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
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