BT18 ( —— )

产品货号. M24975 CAS No. 924811-53-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BT18
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BT18 是一种模拟物，其功能与胶质细胞源性神经营养因子 (GDNF) 相似。
产品描述

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.
体外实验

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines.BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines.BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells. Western Blot Analysis Cell Line:MG87RET cell lines Concentration:50 μM Incubation Time:1, 5, 15, 45, 90 minutes Result:Activated AKT and ERK1/2 in time-dependently.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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CAS Number

924811-53-0
分子量

637.64
分子式

C30H31F4N3O6S
纯度

>98% (HPLC)
溶解度

DMSO: 98 mg/mL (153.69 mM; Need ultrasonic)
SMILES

COc(ccc(S(N(CC1)Cc(cc2OC)c1cc2OC)(=O)=O)c1)c1N(CC1)CCN1C(c(cc1)c(C(F)(F)F)cc1F)=O
化学全称

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