BRD0639

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BRD0639 是一类抑制 PRMT5-substrate adaptor interaction 的抑制剂。BRD0639 是一种 PRMT5 结合基序 (PBM) 竞争剂，可以支持 PBM 依赖的 PRMT5 活性的研究。

BRD0639 is a first-in-class inhibitor of the PRMT5-substrate adaptor interaction. BRD0639 is a PRMT5 binding motif (PBM)-competitive agent that can support studies of PBM dependent PRMT5 activities.

BRD0639 is a first-in-class PBM-competitive small molecule that can support studies of PBM dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions. BRD0639 can engage the cellular target and effectively outcompete binding between full-length PRMT5 and RIOK1 proteins with an IC50 of 7.5 uM and 16 uM in permeabilized and living cells, respectively. BRD0639 reduces SDMA in the same subset of proteins also affected by genetic perturbation of the PRMT5 binding motif (PBM) binding site.

——

——

Others

Other Targets

Histone Methyltransferase

——

——

2760881-74-9

475.95

C21H22ClN5O4S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (525.27 mM; 超声助溶 )

S(NCCC1=CC=CC=N1)(=O)(=O)C2=CC(NC([C@H](C)N3C(=O)C=C(Cl)C=N3)=O)=CC=C2C

——

(-20℃)

With Ice Pack

≥ 2 years