
BPH-1358
CAS No. 5352-53-4
BPH-1358 ( NSC50460 )
产品货号. M24517 CAS No. 5352-53-4
BPH-1358 (NSC50460) 是一种有效的人法尼基二磷酸合成酶 (FPPS) 和十一碳烯基二磷酸合成酶 (UPPS) 抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2446 | 有现货 |
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10MG | ¥3669 | 有现货 |
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25MG | ¥5508 | 有现货 |
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50MG | ¥8262 | 有现货 |
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100MG | ¥11097 | 有现货 |
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500MG | ¥22113 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BPH-1358
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BPH-1358 (NSC50460) 是一种有效的人法尼基二磷酸合成酶 (FPPS) 和十一碳烯基二磷酸合成酶 (UPPS) 抑制剂。
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产品描述BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL).
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体外实验BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively.
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体内实验BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain).
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同义词NSC50460
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通路Others
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靶点Other Targets
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受体human bisphosphonate farnesyl diphosphate synthase
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研究领域——
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适应症——
化学信息
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CAS Number5352-53-4
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分子量601.53
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分子式C32H30Cl2N6O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 6.25 mg/mL (10.39 mM)
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SMILESO=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhu W, et al. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12;58(3):1215-27.
产品手册




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