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BPAM344
CAS No. 1204572-55-3
BPAM344 ( —— )
产品货号. M23375 CAS No. 1204572-55-3
BPAM344 是 KAR 亚基 GluK1b、GluK2a 和 GluK3a 的有效正变构调节剂 (PAM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥680 | 有现货 |
|
| 10MG | ￥1126 | 有现货 |
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| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥4350 | 有现货 |
|
| 100MG | ￥6278 | 有现货 |
|
| 500MG | ￥12879 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BPAM344
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BPAM344 是 KAR 亚基 GluK1b、GluK2a 和 GluK3a 的有效正变构调节剂 (PAM)。
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产品描述BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
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体外实验BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
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体内实验——
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点iGluR
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受体Kainate receptor
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研究领域——
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适应症——
化学信息
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CAS Number1204572-55-3
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分子量242.27
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分子式C10H11FN2O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (1031.91 mM)
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SMILESFC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Larsen A P , Fievre S , Frydenvang K , et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors[J]. Molecular Pharmacology, 2017:mol.116.107599.
