BMS-986251 ( —— )

产品货号. M21869 CAS No. 2041841-30-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BMS-986251
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model.
产品描述

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model. BMS-986251 was studied in mouse acanthosis and imiquimod-induced models of skin inflammation, where it demonstrated robust efficacy comparable to a positive control.
同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

2041841-30-7
分子量

667.61
分子式

C30H29F8NO5S
纯度

>98% (HPLC)
溶解度

——
SMILES

FC(C(F)(F)F)(C(F)(F)F)C1=CC2=C(C=C1)[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)[C@@](N(C([C@@H]5CC[C@@H](C(O)=O)C[C@@H]5C)=O)CC3)([H])CC2
化学全称

(1R,3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)- 2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid

计算器

产品手册

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