
BMS-986235
CAS No. 2253947-47-4
BMS-986235 ( LAR-1219 )
产品货号. M28238 CAS No. 2253947-47-4
BMS-986235 是甲酰肽受体 2 (FPR2) 的选择性口服活性激动剂,对 hFPR2 和 mFPR2 的 EC50 值分别为 0.41 nM 和 3.4 nM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3013 | 有现货 |
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10MG | ¥4504 | 有现货 |
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25MG | ¥7258 | 有现货 |
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50MG | ¥9882 | 有现货 |
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100MG | ¥13365 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BMS-986235
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BMS-986235 是甲酰肽受体 2 (FPR2) 的选择性口服活性激动剂,对 hFPR2 和 mFPR2 的 EC50 值分别为 0.41 nM 和 3.4 nM。
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产品描述BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.(In Vitro):BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation.(In Vivo):In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L?h, and 24%, respectively.
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体外实验——
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体内实验Animal Model:Male C57BL/6 miceDosage:0.3 mg/kg Administration:P.o.; daily for 24 daysResult:Left ventricle (LV) chamber remodeling is attenuated after myocardial infarction (MI). Reduced infarct length by 39% relative to vehicle.Animal Model:Male mice (BALB/cCrSlc)Dosage:1 mg/kg Administration:P.o. (Pharmacokinetic Analysis)Result:The Cmax, T1/2, AUC0-inf, and bioavailability (BA) values were 160 nmol/L, 0.68 hours, 120 nmol/L?h, and 24%, respectively.
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同义词LAR-1219
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通路Others
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靶点Other Targets
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受体LDL|TNF-α|Antioxidant
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研究领域——
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适应症——
化学信息
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CAS Number2253947-47-4
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分子量361.34
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分子式C18H17F2N3O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (276.75 mM)
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SMILESO=C(NC=1C=CC=CC1)NC2C(=O)NCC2C=3C(F)=CC(OC)=CC3F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Sharma S, et al. Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. Eur J Med Chem. 2010;45(11):5150-5156.
产品手册




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