021-51111890
购物车（0）
sales@molnova.cn
BMS-986141
CAS No. 1478711-48-6
BMS-986141 ( —— )
产品货号. M35754 CAS No. 1478711-48-6
BMS-98614 是一种口服活性的、选择性的凝血酶受体蛋白酶激活受体-4 (PAR-4) (protease-activated receptor-4 (PAR-4)) 拮抗剂，其 IC50 值为 0.4 nM。BMS-98614 具有优异的抗血栓功效。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥10168 | 有现货 |
|
| 5MG | ￥12759 | 有现货 |
|
| 10MG | ￥15908 | 有现货 |
|
| 25MG | ￥22052 | 有现货 |
|
| 50MG | ￥29560 | 有现货 |
|
| 100MG | ￥39245 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称BMS-986141
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述BMS-98614 是一种口服活性的、选择性的凝血酶受体蛋白酶激活受体-4 (PAR-4) (protease-activated receptor-4 (PAR-4)) 拮抗剂，其 IC50 值为 0.4 nM。BMS-98614 具有优异的抗血栓功效。
-
产品描述BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC50 value of 0.4 nM. BMS-98614 has excellent antithrombotic effect.
-
体外实验BMS-986141 (compound 49) (0-1 μM) inhibits platelet aggregation induced by PAR4 agonist peptide with an IC50 value of 2.2 nM.
-
体内实验BMS-986141 (compound 49) shows a slight but significant prolongation of KBT (kidney bleeding time) and demonstrates excellent anti-thrombotic efficacy at 0.5 mg/kg in cynomolgus monkey.Animal Model:Monkey arterial thrombosis (AT) and mesenteric bleeding time (MBT) models Dosage:0.05, 0.1, 0.5 mg/kg Administration:p.o., 2 hours Result:Inhibited PAR4-AP-induced platelet aggregation in human and monkey blood with IC50 of 1.8 and 1.3 nM, respectively.Reduced the thrombus weight by 36%, 63% and 88% at concentrations of 0.05, 0.1 and 0.5 mg/kg, respectively in AT model.
-
同义词——
-
通路GPCR/G Protein
-
靶点PAR
-
受体Protease-activated Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number1478711-48-6
-
分子量561.63
-
分子式C27H23N5O5S2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO(CC=1N=C(SC1)C2=CC=C(C(N(C)C)=O)C=C2)C3=C4C(OC(=C4)C5=CN6C(=N5)SC(OC)=N6)=CC(OC)=C3
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. E Scott Priestley, et al. Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem. 2022 Jul 14;65(13):8843-8854.?
产品手册
关联产品
-
Protease-Activated R...
一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。
-
SSR128129E
SSR128129E 是一种变构且口服活性的 FGFR1 抑制剂 (IC50: 1.9 μM)，但不影响其他相关 RTK。
-
FSLLRY-NH2
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
