BMS-919373 ( BMS919373 )

产品货号. M11139 CAS No. 1272353-82-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BMS-919373
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
产品描述

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued
同义词

BMS919373
通路

Cell Cycle/DNA Damage
靶点

Potassium Channel
受体

Potassium Channel
研究领域

Cardiovascular Disease
适应症

Heart Arrhythmia

CAS Number

1272353-82-8
分子量

468.54
分子式

C25H20N6O2S
纯度

>98% (HPLC)
溶解度

——
SMILES

C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
化学全称

5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.

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