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BMS-8
CAS No. 1675201-90-7
BMS-8 ( BMS8 | BMS 8 | BMS-8 )
产品货号. M27858 CAS No. 1675201-90-7
BMS-8 是一种新型 PD-1/PD-L1 相互作用抑制剂 (IC50: 7.2 μM)，通过直接与 PD-L1 结合并诱导 PD-L1 同二聚体的形成。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥616 | 有现货 |
|
| 10MG | ￥1077 | 有现货 |
|
| 25MG | ￥2292 | 有现货 |
|
| 50MG | ￥3686 | 有现货 |
|
| 100MG | ￥5443 | 有现货 |
|
| 500MG | ￥11583 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BMS-8
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BMS-8 是一种新型 PD-1/PD-L1 相互作用抑制剂 (IC50: 7.2 μM)，通过直接与 PD-L1 结合并诱导 PD-L1 同二聚体的形成。
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产品描述BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.(In Vitro):BMS-8 has a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124.
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体外实验BMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124.
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体内实验——
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同义词BMS8 | BMS 8 | BMS-8
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通路Immunology/Inflammation
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靶点PD-1/PD-L1
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受体Wnt/beta-catenin
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研究领域——
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适应症——
化学信息
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CAS Number1675201-90-7
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分子量494.429
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分子式C27H28BrNO3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (168.54 mM)
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SMILESCc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol. 2011 May 20;6(5):452-65.
产品手册
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