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BMS-3
CAS No. 1338247-30-5
BMS-3 ( BMS-3; BMS 3; BMS3 )
产品货号. M17955 CAS No. 1338247-30-5
BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
|
| 5MG | ￥608 | 有现货 |
|
| 10MG | ￥964 | 有现货 |
|
| 25MG | ￥1968 | 有现货 |
|
| 50MG | ￥3281 | 有现货 |
|
| 100MG | ￥4779 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BMS-3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.
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产品描述BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
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同义词BMS-3; BMS 3; BMS3
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通路Others
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靶点Other Targets
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受体LIMK1;LIMK2
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研究领域Cancer
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适应症——
化学信息
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CAS Number1338247-30-5
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分子量429.27
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分子式C17H12Cl2F2N4OS
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纯度98%
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溶解度DMSO : ≥ 30 mg/mL6; 9.89 mM
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SMILESO=C(Nc1ncc(s1)c2cc(nn2c3c(Cl)cccc3Cl)C(F)F)C4CC4
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化学全称N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.
产品手册
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